When something goes wrong mentally, naturally it affects the physical.
Ascendant is the basic house which denotes body.
Its lord plays the next role.
The signifactor(karaka) of lagna/ascendant, namely the Sun is the third.
Chandra is the mind.
when there is a mismatch between these factors, or when there is dusthithi(bad positioning) or duravastha(bad state), there has to be some anarchism within the body.
Now, if mars/ketu/sani afflicts 6th, 8th or 12th along with the above mentioned factors,
we can expect cancer.
but surely, there is hope.